Medication
Developed in India: eye drops that can replace your reading glasses
New Delhi: An eye drop that can replace reading glasses for middle-aged people was launched in India on Tuesday, following the approval of marketing authorization by the Drug Controller General of India (DCGI) last month. This will be the first time that India has dropped its eyes.
The drug contains 1.25 percent of pilocarpine hydrochloride. Pilocarpine is a plant-derived compound that has been used for decades to treat various eye conditions and dry mouth, and to reduce eye pressure, among other uses.
It is intended to treat presbyopia, a common age-related vision condition that often affects people over 40, causing the eyes to gradually lose their ability to focus on nearby objects.
Eye drops have been developed and launched by Mumbai-based pharmaceutical firm Entod Pharmaceuticals under the name PresVu. One vial of the eye drop, designed to last for about a month, will cost Rs 345.
A similar product was launched in the US in 2022 under the name Vuity, after regulatory approval by the US Food and Drug Administration (US FDA). Vuity is the only FDA-approved eye drop that can treat age-related blurred vision.
Nikhil Masurkar, CEO of Entod Pharmaceuticals, told ThePrint that the onset of eye drops in India is the result of extensive research that began in 2019.
It is estimated, he added, that about 45 percent of Indians above the age of 40 have presbyopia.
The drug is expected to be available in pharmacies across India by October, the CEO said.
Data from phase 3 clinical trials of the drug—conducted in 250 patients across 10 sites—submitted to DCGI showed that it works well in people aged 40 to 55 with mild to moderate presbyopia, temporarily correcting vision problems.
Eye drops should only be used under an eye doctor’s prescription. One drop of the medicine should be put in each eye every day. The effect lasts about six hours.
Each eye can be instilled with each drop three to six hours after the first drop. This can correct the blurred vision for another three hours.
Entod Pharmaceuticals states that the medicine starts working within 15 minutes of use but the full benefits may be seen after 15 days of use.
Dr. Dhananjay Bakhle, chief pharmacist and consultant at Entod Pharmaceuticals, said that for patients with presbyopia, eye drops offer a non-invasive option that can improve vision without the need for reading glasses.
«Its rapid action and safety profile, demonstrated in clinical trials, make it an important addition to the treatment arsenal,» Bakhle told ThePrint.
Also read: Rotavirus vaccine has reduced deaths in India by a third, curbing antibiotic misuse, finds US study.
‘It’s better than India’s eyes’
CEO Masurkar said PresVu has adjuvants—other than the active pharmaceutical ingredient—that are different from Vuity. This is because Indian irises are often multi-colored.
The company has also applied for a patent for the product based on its design and manufacturing process, and stated that the material form not only allows patients to remove reading glasses, but also helps eye cream as a side benefit.
These eye drops use advanced buffer technology to quickly adjust the pH (the scale used to measure how acidic or basic a substance is) to ensure consistent performance and safety for long-term use, remembering that such drops will be used for many years, «Entod Pharmaceuticals said in a statement.
Dr. Aditya Sethi, a Delhi-based ophthalmologist, explained to ThePrint that while presbyopia has long been managed with reading glasses, contact lenses and surgical intervention, PresVu offers an alternative advanced that increases the vision for 15 minutes.
«This new treatment option aims to significantly improve the quality of life for many people, allowing them to carry out daily activities with new ease,» said Dr Sethi.
The eye doctor added that it is important to monitor symptoms and seek medical advice if blurred near vision interferes with reading, near work, or other activities.
However, the Central Drug Control Organization (CDSCO), headed by the DCGI, has not yet issued a license issued for marketing approval of the drug. A prescription for a drug mentions contraindications or adverse events associated with it.
CDSCO, while granting marketing approval to Entod Pharmaceuticals for PresVu, requested phase 4 data, which is collected after the drug is marketed in the country.
US FDA lists potential problems with Vuity.
Adverse effects reported in less than 5 percent of clinical trial participants after using Vuity were headache and conjunctival hyperemia or red eye.
A small number of participants (1 to 5 percent) also reported side effects such as blurred vision, eye pain, blurred vision, eye irritation, and increased fluid (flow of tears) after using Vuity.
(Edited by Radifah Kabir)
Also read: US scientists are developing a Parkinson’s implant, which they say can control symptoms better than conventional treatment
#Developed #India #eye #drops #replace #reading #glasses
Strengthening Capacity to Support Growing Demand in the Functional Food Sector
NEW YORK, December 3, 2024 /PRNewswire/ — 5WPR, one of America’s leading and largest independent PR firms, is proud to announce the expansion of its Health & Wellness division to include focusing on Functional Nutrition. This strategic move reflects 5W’s commitment to staying ahead of industry trends and evolving its services to meet the needs of this rapidly changing market.
With increasing consumer interest in functional foods, brands are seeking expert guidance to differentiate themselves in a competitive market. In response, 5WPR has expanded its services to cover key areas within the nutrition industry, including gut health, supplements and functional drinks, performance and sports nutrition, protein powder, probiotics, weight management, collagen peptides, dietary powder, functional mushrooms. , nutrition, and pet health.
Functional nutrition has become an influence in the field of health and wellness, fueled by increased consumer awareness and demand for products that provide more than basic nutritional benefits. According to the latest data from Open PR, gut health products alone are estimated to grow by approximately 8% annually between 2024 and 2031. Additionally, the Food Institute is report that e-commerce has emerged as the fastest growing channel for supplements in 2023, an increase of 9.5%, highlighting the importance of a strong online presence. Performance nutrition has also seen significant growth, with categories such as hydration and electrolytes increasing by 52.2%, and creatine sales increasing by an impressive 114.4%, according to the New Hope Network.
«The functional nutrition market is not only growing; it is defining the health and wellness industry,» he said. Ilisa WirginManaging Partner and EVP of 5WPR’s Health & Wellness and Beauty division. «Consumers are looking for products that improve their overall well-being, improve performance, and support recovery, which makes it an exciting and exciting segment. Our expanded focus will help us helping customers in this area to grow their product profiles, align with their target audience, and deliver meaningful results.»
5WPR’s track record in health and wellness includes working with some of the most recognized brands in fitness, nutrition, and personal care. The agency’s expertise in media relations, influencer partnerships, thought leadership, digital strategy, and affiliate marketing ensures that clients in the nutrition space receive structured, comprehensive, and measurable support.
#5WPR #Expands #Health #Wellness #Divide #Focus #Functional #Nutrition
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Lady Gabriella Kingston’s husband took his own life after taking anti-depressants prescribed by his doctor, a coroner has said.
Thomas Kingston, who married Prince and Princess Michael of Kent’s daughter at Windsor Castle in 2019, died of a head injury and a gun was found next to his body on March 25 at his parents’ home in the Cotswolds.
At an inquest into her death held at Gloucestershire Coroner’s Court on Tuesday, Lady Gabriella, 43, asked people to be warned about the side effects of drugs used to treat mental health conditions or she feared people would many may die.
The inquest was told that the 45-year-old fundraiser had been given sertraline, a drug used to treat depression, and zopiclone, a sleeping pill, by a doctor at the Royal Mews Surgery, Buckingham Palace’s staff-run practice. of the palace. , after complaining of trouble sleeping after stress at work.
Mr Kingston went back to surgery saying they were not making him feel better, and his doctor switched him from sertraline to citalopram, a similar drug.
In the first days of his death, Mr. Kingston had stopped taking medication, and toxicology tests showed caffeine and a small amount of zopiclone in his system.
In a statement read out by Katy Skerrett, chief minister of Gloucestershire, Lady Gabriella, 43, said: «[Work] it has been a challenge for her over the years but I highly doubt it would have made her suicidal, and she seemed to have improved a lot.
If there was something that was bothering him, I’m sure he would have said that he was struggling a lot.
The fact that he committed suicide in the home of his beloved parents suggests that the decision was the result of a sudden impulse.
He said he believed her death «may have been precipitated» by an adverse reaction to medication she had started, and then stopped, taking in the weeks leading up to her death.
«In the absence of any evidence of propensity, it seems very likely to me that she had a bad reaction to the pills that made her take her own life,» Lady Gabriella said.
«I believe that anyone who takes pills like these should be warned about the side effects to prevent future deaths.
If this can happen to Tom, it can happen to anyone.
In his final weeks, Mrs Gabriella said, her husband «seemed normal», except for the morning after he first took zopiclone, which she said made him seem «he he’s a bit confused».
In his statement, he described their marriage as one of «deep love and trust» and said he never gave any suicidal thoughts to himself or others.
He also said he was deeply affected by his friend’s suicide and «the negative impact it had on other people’s loved ones».
Miss Gabriella, whose wedding to Mr Kingston included Queen Elizabeth II and the late Duke of Edinburgh among the guests, wept as she sat in the coroner’s court as her statement was read.
Wrapping up the story, Ms Skerrett said: «Mr Kingston took his own life with a self-inflicted gunshot wound to the head.
«The evidence of his wife, family and business partner all support the lack of intent to kill himself.
He was suffering from the side effects of the medicine he had just been given.»
He said he intends to make a report on the prevention of future deaths, which will be sent to medical societies.
Mr. Kingston’s father, William Martin Kingston, wept as he described finding his son in the locked bathroom of the annexe, having used a doorknob to break the door.
He told the court that his son has always had a strong, unstable character, as he previously suffered from pain that left him needing help to climb the stairs.
She told the coroner that before her son’s death there did not appear to be any evidence of suicide, and there was no will, describing the process as «reckless.» very» who was «out of shape».
Dr David Healy, a psychiatrist who gave evidence at the hearing, said zopiclone could also cause anxiety, while sertraline and citalopram were both serotonin reuptake inhibitors (SSRIs), and while exactly the same.
Dr Healy said Mr Kingston’s complaints that sertraline continued to cause him anxiety was a sign SSRIs «didn’t suit him», and he should not have been prescribed the same thing again.
He said the guidelines and labels for SSRIs were not clear enough about using the drug first, or what the effect would be when switching from one to another.
He said: «We need a clearer statement that these drugs can cause people to kill themselves who would otherwise not kill themselves.
Speaking to the doctor, Martin Porter, the family’s adviser, said: «The family is not to blame (her doctor) Dr Naunton Morgan, he worked like a good doctor.
But the question is whether there is enough advice to doctors about SSRIs.
#Lady #Gabriellas #husband #killed #antidepressants
AlayaCare’s Cloud-Based EHR Platform Onboards Home Care Benefits of the Home Care Center
NEW YORK, Dec. 03, 2024 (GLOBE NEWSWIRE) — AlayaCare, a global technology platform for home and community care, is pleased to announce today the successful implementation of Care Advantage, Inc.
Care Advantage, Inc. is the largest independent home health provider in the mid-Atlantic. The company provides personal services, home care and home health services throughout Virginia, Maryland, Delaware, North Carolina and Washington DC.
Care Advantage’s leadership recognized AlayaCare’s ability to provide a risk-free, user-friendly solution that could grow with the company. The decision to collaborate with AlayaCare was made after an extensive selection process that considered the opinions of experts from its internal teams, emphasizing the importance of a holistic approach to choosing a technology partner.
«We were looking for a partner, not just a vendor, who could help us build and transform our system over time,» said Tim Hanold, CEO of Care Advantage. «AlayaCare’s commitment to working together and creating a true partnership were key factors in our final decision.»
Despite the challenges presented by the published timeline and coverage of more than 50 locations, both teams worked closely to customize the system to meet Care Advantage’s needs.
«Implementing a system of this size in such a short period of time was no small feat,» said Jaron Clay, VP of Integrations. «The speed of the rollout was only possible with good coordination and both groups are committed to having Care Advantage running smoothly and feeling the benefits of the new system as soon as possible.»
The move to AlayaCare underscores Care Advantage’s commitment to innovation and excellence in home care, ensuring clients and their families receive the best possible care and support. As a highly data-driven and growth-focused company, the flexibility of AlayaCare’s platform enables large operations to enter new markets while maintaining a high level of customer care. own and create new opportunities for its custodians.
«There is a shared understanding and vision between us and the AlayaCare team,» said Tim Hanold. «They support our unwavering commitment to excellence in the classroom and are part of the reason we chose them. We feel this is the platform to take us to that level. We are delighted to have AlayaCare as a partner our technology,» he concluded. «Together, we’re setting new standards for home care.»
#AlayaCares #CloudBased #EHR #Platform #Onboards #Home #Care #Benefits #Home #Care #Center
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