Medication
Breast cancer: Honey extract reduced tumor growth by 84% in mice
- About 80% of all breast cancer diagnoses are ER-positive.
- Although there are traditional treatments available for ER-positive breast cancer, some people also choose to follow complementary and alternative therapies.
- Researchers at the University of California, Los Angeles say that Manuka honey is an alternative method of prevention and treatment for breast cancer, especially ER-positive cancer, in animal cell models and cancer .
As of 2022, approximately 2.3 million women worldwide will have been diagnosed with breast cancer, making it the second most common cancer in the world.
About 80% of all breast cancer diagnoses are estrogen receptor-positive (ER-positive). This means that breast cancer cells have receptors that bind to the hormone estrogen and may require estrogen to grow.
Current treatment options available for ER-positive breast cancer include
Previous studies have also examined this
Now researchers at the University of California, Los Angeles say that Manuka honey can also be used as an alternative method of prevention and treatment for breast cancer, especially ER-positive cancer, in animal models. and cancer.
The study was recently published in the journal Energy.
Manuka honey is made by bees that collect the nectar of the Manuka tree, which is native to Australia and New Zealand.
For this study, researchers used cancer and breast cancer cell types to determine how Manuka honey might affect breast cancer.
«Manuka honey contains many unique nutrients and bioactive compounds that can contribute to health benefits such as ‘.
«As we mentioned in the published manuscript, there have been several traditional, ancient and classical reports about the anti-tumor effects of Manuka honey, which is also described as having.
During their research, Pietras and his team found that Manuka honey caused an 84% reduction in tumor growth in mice with ER-positive breast cancer cells without affecting healthy cells. well of the breasts or cause serious side effects.
«In one of the most rigorous trials we’ve done, administration of Manuka honey alone inhibited the growth of ER-positive breast tumors by 84%, resulting in a noticeable reduction of tumor size.» Pietras said.
«Although promising, our findings highlight the need for further research into the use of natural ingredients, such as Manuka honey, for anti-tumor efficacy and potential chemoprevention and research on the molecular pathways underlying these actions.»
– Richard Pietras, MD, PhD
The scientists found that a high amount of Manuka honey was associated with a significant reduction in the growth of cancer cells.
«Dose escalation studies are common in drug development studies for discovery purposes
In addition, researchers found that using Manuka honey helped reduce levels of
«The progression of breast cancer involves multiple, complex pathways,» Pietras explained. “In the case of ER-positive breast cancer, estrogens binding to and activating the estrogen receptor (ER) are the main drivers of uncontrolled tumor growth. Binding of ERs to specific sites on DNA leads to the initiation of a gene transcription program that orchestrates many downstream activities to support cancer development. ”
«The mechanisms of antitumor activity of Manuka honey and its compounds are suggested to include activity as
In this study, Pietras said, he and his team investigated the potential antitumor effects of Manuka honey on estrogen positive and negative breast cancer.
«We have also identified potential ways to demonstrate the effectiveness of Manuka honey,» he continued. «Activation of important intracellular signaling pathways such as AMPK and inhibition of downstream mTOR signaling – a ubiquitous kinase enzyme that controls cell growth, proliferation, metabolism to support the growth of tumor – as well as STAT3 that plays an important role in the regulation of cell death, angiogenesis, metastasis, and immune responses also appear to be molecular targets involved in the antitumor activity of eggs of Manuka bees.»
After reviewing the study, Bhavana Pathak, MD, a hematologist and clinical oncologist at MemorialCare Cancer Institute Orange Coast and Saddleback Medical Centers in Orange County, CA, said. MNT he found the study very interesting and promising.
«I am concerned about the effect of consuming a compound that can increase glucose, which is not normally recommended for cancer. However, its overall effect is the one that should be considered,» Pathak continued.
«One treatment is no longer acceptable, first it depends on the patient’s biology and then it depends on the patient’s choice,» he added. «With fewer side effects, this could be an alternative for those looking for a natural supplement or opting out of treatment altogether. The next steps are testing in humans and determining the safe dosage and effect of the treatment .”
MNT and spoke with Monique Richard, MS, RDN, LDN, FAND, RYT-200, registered dietitian and owner of Nutrition-In-Sight, about this study.
«Despite the many agreements and beneficial properties resulting from the unique ingredients of Manuka honey, the results of the study on the prevention of tumor growth surprised me,» said Richard. «It is important to note that the study was on mice, however, the findings encourage further research to see if the results can be replicated.»
«It is possible that Manuka honey’s long list of ‘anti-‘ benefits – antibacterial, antimicrobial, antioxidant, anti-inflammatory – could be extended with ‘antitumor,’ ‘antiproliferative,’ and ‘antimetastatic ‘ potential additive effects. This potent gooey liquid from New Zealand’s Manuka bush pollen is Mother Nature’s gold and has the potential to aid in the treatment of breast cancer without the dangerous toxic side effects.»
– Monique Richard, MS, RDN, LDN, FAND, RYT-200
For readers who wish to include Manuka honey in their diet for the many ‘anti-‘ benefits, Richard recommends following a «less is more» approach:
- try it with a cup of green or black tea
- add hot oatmeal or overnight oats
- mix with nut butter or yogurt
- drizzle over fruit, whole-grain toast, or popcorn
- add to smoothies, roasted vegetables (think carrots, turnips, or potatoes), or granola
- Use in salad dressing, marinade or glaze
«There’s no need to be shy like Winne-the-Pooh with a jar of Manuka honey as it’s high in carbohydrates as it’s mainly glucose-aka sugar, but a teaspoon or a drizzle it can contribute in a special way while providing health benefits.. Other good options to improve the taste and take advantage of this natural treasure are many they are the main ones to reap the fruits of this honey,» he said.
#Breast #cancer #Honey #extract #reduced #tumor #growth #mice
Strengthening Capacity to Support Growing Demand in the Functional Food Sector
NEW YORK, December 3, 2024 /PRNewswire/ — 5WPR, one of America’s leading and largest independent PR firms, is proud to announce the expansion of its Health & Wellness division to include focusing on Functional Nutrition. This strategic move reflects 5W’s commitment to staying ahead of industry trends and evolving its services to meet the needs of this rapidly changing market.
With increasing consumer interest in functional foods, brands are seeking expert guidance to differentiate themselves in a competitive market. In response, 5WPR has expanded its services to cover key areas within the nutrition industry, including gut health, supplements and functional drinks, performance and sports nutrition, protein powder, probiotics, weight management, collagen peptides, dietary powder, functional mushrooms. , nutrition, and pet health.
Functional nutrition has become an influence in the field of health and wellness, fueled by increased consumer awareness and demand for products that provide more than basic nutritional benefits. According to the latest data from Open PR, gut health products alone are estimated to grow by approximately 8% annually between 2024 and 2031. Additionally, the Food Institute is report that e-commerce has emerged as the fastest growing channel for supplements in 2023, an increase of 9.5%, highlighting the importance of a strong online presence. Performance nutrition has also seen significant growth, with categories such as hydration and electrolytes increasing by 52.2%, and creatine sales increasing by an impressive 114.4%, according to the New Hope Network.
«The functional nutrition market is not only growing; it is defining the health and wellness industry,» he said. Ilisa WirginManaging Partner and EVP of 5WPR’s Health & Wellness and Beauty division. «Consumers are looking for products that improve their overall well-being, improve performance, and support recovery, which makes it an exciting and exciting segment. Our expanded focus will help us helping customers in this area to grow their product profiles, align with their target audience, and deliver meaningful results.»
5WPR’s track record in health and wellness includes working with some of the most recognized brands in fitness, nutrition, and personal care. The agency’s expertise in media relations, influencer partnerships, thought leadership, digital strategy, and affiliate marketing ensures that clients in the nutrition space receive structured, comprehensive, and measurable support.
#5WPR #Expands #Health #Wellness #Divide #Focus #Functional #Nutrition
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Lady Gabriella Kingston’s husband took his own life after taking anti-depressants prescribed by his doctor, a coroner has said.
Thomas Kingston, who married Prince and Princess Michael of Kent’s daughter at Windsor Castle in 2019, died of a head injury and a gun was found next to his body on March 25 at his parents’ home in the Cotswolds.
At an inquest into her death held at Gloucestershire Coroner’s Court on Tuesday, Lady Gabriella, 43, asked people to be warned about the side effects of drugs used to treat mental health conditions or she feared people would many may die.
The inquest was told that the 45-year-old fundraiser had been given sertraline, a drug used to treat depression, and zopiclone, a sleeping pill, by a doctor at the Royal Mews Surgery, Buckingham Palace’s staff-run practice. of the palace. , after complaining of trouble sleeping after stress at work.
Mr Kingston went back to surgery saying they were not making him feel better, and his doctor switched him from sertraline to citalopram, a similar drug.
In the first days of his death, Mr. Kingston had stopped taking medication, and toxicology tests showed caffeine and a small amount of zopiclone in his system.
In a statement read out by Katy Skerrett, chief minister of Gloucestershire, Lady Gabriella, 43, said: «[Work] it has been a challenge for her over the years but I highly doubt it would have made her suicidal, and she seemed to have improved a lot.
If there was something that was bothering him, I’m sure he would have said that he was struggling a lot.
The fact that he committed suicide in the home of his beloved parents suggests that the decision was the result of a sudden impulse.
He said he believed her death «may have been precipitated» by an adverse reaction to medication she had started, and then stopped, taking in the weeks leading up to her death.
«In the absence of any evidence of propensity, it seems very likely to me that she had a bad reaction to the pills that made her take her own life,» Lady Gabriella said.
«I believe that anyone who takes pills like these should be warned about the side effects to prevent future deaths.
If this can happen to Tom, it can happen to anyone.
In his final weeks, Mrs Gabriella said, her husband «seemed normal», except for the morning after he first took zopiclone, which she said made him seem «he he’s a bit confused».
In his statement, he described their marriage as one of «deep love and trust» and said he never gave any suicidal thoughts to himself or others.
He also said he was deeply affected by his friend’s suicide and «the negative impact it had on other people’s loved ones».
Miss Gabriella, whose wedding to Mr Kingston included Queen Elizabeth II and the late Duke of Edinburgh among the guests, wept as she sat in the coroner’s court as her statement was read.
Wrapping up the story, Ms Skerrett said: «Mr Kingston took his own life with a self-inflicted gunshot wound to the head.
«The evidence of his wife, family and business partner all support the lack of intent to kill himself.
He was suffering from the side effects of the medicine he had just been given.»
He said he intends to make a report on the prevention of future deaths, which will be sent to medical societies.
Mr. Kingston’s father, William Martin Kingston, wept as he described finding his son in the locked bathroom of the annexe, having used a doorknob to break the door.
He told the court that his son has always had a strong, unstable character, as he previously suffered from pain that left him needing help to climb the stairs.
She told the coroner that before her son’s death there did not appear to be any evidence of suicide, and there was no will, describing the process as «reckless.» very» who was «out of shape».
Dr David Healy, a psychiatrist who gave evidence at the hearing, said zopiclone could also cause anxiety, while sertraline and citalopram were both serotonin reuptake inhibitors (SSRIs), and while exactly the same.
Dr Healy said Mr Kingston’s complaints that sertraline continued to cause him anxiety was a sign SSRIs «didn’t suit him», and he should not have been prescribed the same thing again.
He said the guidelines and labels for SSRIs were not clear enough about using the drug first, or what the effect would be when switching from one to another.
He said: «We need a clearer statement that these drugs can cause people to kill themselves who would otherwise not kill themselves.
Speaking to the doctor, Martin Porter, the family’s adviser, said: «The family is not to blame (her doctor) Dr Naunton Morgan, he worked like a good doctor.
But the question is whether there is enough advice to doctors about SSRIs.
#Lady #Gabriellas #husband #killed #antidepressants
AlayaCare’s Cloud-Based EHR Platform Onboards Home Care Benefits of the Home Care Center
NEW YORK, Dec. 03, 2024 (GLOBE NEWSWIRE) — AlayaCare, a global technology platform for home and community care, is pleased to announce today the successful implementation of Care Advantage, Inc.
Care Advantage, Inc. is the largest independent home health provider in the mid-Atlantic. The company provides personal services, home care and home health services throughout Virginia, Maryland, Delaware, North Carolina and Washington DC.
Care Advantage’s leadership recognized AlayaCare’s ability to provide a risk-free, user-friendly solution that could grow with the company. The decision to collaborate with AlayaCare was made after an extensive selection process that considered the opinions of experts from its internal teams, emphasizing the importance of a holistic approach to choosing a technology partner.
«We were looking for a partner, not just a vendor, who could help us build and transform our system over time,» said Tim Hanold, CEO of Care Advantage. «AlayaCare’s commitment to working together and creating a true partnership were key factors in our final decision.»
Despite the challenges presented by the published timeline and coverage of more than 50 locations, both teams worked closely to customize the system to meet Care Advantage’s needs.
«Implementing a system of this size in such a short period of time was no small feat,» said Jaron Clay, VP of Integrations. «The speed of the rollout was only possible with good coordination and both groups are committed to having Care Advantage running smoothly and feeling the benefits of the new system as soon as possible.»
The move to AlayaCare underscores Care Advantage’s commitment to innovation and excellence in home care, ensuring clients and their families receive the best possible care and support. As a highly data-driven and growth-focused company, the flexibility of AlayaCare’s platform enables large operations to enter new markets while maintaining a high level of customer care. own and create new opportunities for its custodians.
«There is a shared understanding and vision between us and the AlayaCare team,» said Tim Hanold. «They support our unwavering commitment to excellence in the classroom and are part of the reason we chose them. We feel this is the platform to take us to that level. We are delighted to have AlayaCare as a partner our technology,» he concluded. «Together, we’re setting new standards for home care.»
#AlayaCares #CloudBased #EHR #Platform #Onboards #Home #Care #Benefits #Home #Care #Center
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